The Significance of Vitamin D Storage in Adipose Tissue

University of Tromso (UiT)

Status and phase: Withdrawn; Phase 2

Conditions: Obesity

Treatments: Drug: placebo; Drug: cholecalciferol

Study type: Interventional

Funder types: Other

Identifiers

NCT01728987

TromsøEndo-2012-1

Details and patient eligibility

About

The study will examine the role of adipose tissue in vitamin D physiology, particularly its role as a depot. the study is randomized double blind and placebo controlled.

Full description

vitamin d versus placebo will be given for 12 months. Biopsies will be taken at baseline and every 6 month for 2 years. Blood samples will be collected every 6th month. the study will thus give information on storage during vitamin d supplementation as well as use of vitamin d fat stores after stopping vitamin D supplementation

Sex: All

Ages: 20 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy subjects

Exclusion criteria

• hypercalcemia
• pregnancy
• women without safe contraception

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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0 participants in 2 patient groups, including a placebo group

cholecalciferol

Active Comparator group

Description:

vitamin d (cholecalciferol) will be given as a capsule of 20.000 Iu twice a week

Treatment:

Drug: cholecalciferol

placebo

Placebo Comparator group

Description:

the placebo capsules are looking identical to the vitamin d capsules and contain medium chain triglycerides and arachis oil

Treatment:

Drug: placebo