The Skin Microbiome in Graft Versus Host Disease

University Hospital Basel

Status: Active, not recruiting

Conditions: Graft Versus Host Disease; Graft Versus Host Disease in Skin; Skin Microbiome

Treatments: Diagnostic Test: additional blood sampling; Diagnostic Test: Skin swabs; Diagnostic Test: Skin punch biopsies

Study type: Observational

Funder types: Other

Identifiers

NCT04231500

2019-01939 sp19Mueller5;

Details and patient eligibility

About

Based on the evidence on the impact of the intestinal microbiome on the Graft Versus Host Disease (GVHD) after allogeneic Hematopoietic Stem Cell Transplantation (allo-HSCT), it is hypothesized that the skin-microbiome may play a role in cutaneous GVHD as well. Therefore, this study aims at investigating the skin-microbiota of patients with GVHD after allo-HSCT and of patients without GVHD after allo-HSCT.

Enrollment: 74 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• undergoing allo-HSCT at the University Hospital Basel

Exclusion criteria

• missing ability to judge
• illiteracy or lack of German, French or English language

Trial design

74 participants in 2 patient groups

patients with GVHD after allo-HSCT

Description:

Exploration of the skin-microbiota in patients with GVHD after allo-HSCT by sampling of skin swabs and a skin punch biopsy before conditioning procedure and additional skin biopsies from affected and healthy skin sites in case of GVHD

Treatment:

Diagnostic Test: Skin punch biopsies

Diagnostic Test: Skin swabs

Diagnostic Test: additional blood sampling

patients without GVHD after allo-HSCT

Description:

Exploration of the skin-microbiota in patients without GVHD after allo-HSCT by sampling of skin swabs and a skin punch biopsy before conditioning procedure

Treatment:

Diagnostic Test: Skin punch biopsies

Diagnostic Test: Skin swabs

Diagnostic Test: additional blood sampling