The South Texas Aging Registry and Repository (STARR)

The University of Texas System (UT)

Status: Completed

Conditions: Aging

Study type: Observational

Funder types: Other

Identifiers

NCT05835388

HSC20150610H

Details and patient eligibility

About

This research registry and repository was designed because the investigators want to learn about how to improve the health and quality of life of older adults.

Full description

The South Texas Aging Registry and Repository (STARR) is a database and specimen resource of community dwelling adults from the South Texas area who are interested in volunteering for research studies on aging. The goal is to assist in the inclusion of older adults in clinical research studies and to help to increase the quantity and quality of research relating to them. This registry and repository can be used for various purposes ranging from describing the natural history of aging, identifying risk factors for premature aging, and the real-world effectiveness of life-extending therapies. Collection and storage of biological samples and patient-reported data from of Individuals can help advance research and the development of new awareness of basic mechanisms that play a part in healthy aging or premature death.

Enrollment: 149 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria STARR:

-Age 18 years or older

Inclusion Criteria KAPP Sen TMC:

-Age 20 years and older

Exclusion Criteria STARR:

• Inability to provide informed consent
• Pregnancy

Exclusion Criteria KAPP Sen Tissue Mapping Center (TMC) Study:

• Diabetes
• Hypertension with end-organ damage
• BMI>30
• GFR<60 ml/min/1.73 m2
• Cardiovascular disease
• Pancreatitis
• Malignancy other than non-melanoma skin cancers
• Active, uncontrolled pulmonary, hepatic, infectious, gastrointestinal, endocrine, neurologic, or inflammatory disease.
• Chronic use of systemic steroids or use of agents with senolytic activity
• Any disease or condition considered to be exclusionary based on the clinical option and discretion of PI

Trial design

149 participants in 2 patient groups

Primary Study

Description:

Community dwelling adults from the South Texas area who are interested in volunteering for research studies on aging. This will facilitate the inclusion of older adults and minority in research studies and help to increase the quantity and quality of research relating to them.

KAPP Sen Tissue Mapping Study

Description:

The substudy KAPP Sen TMC will enroll eligible STARR participants to undergo repeat assessments over two years. KAPP Sen TMC is a collaborative effort between UT Health San Antonio, Jackson Laboratory for Genomic Medicine (JAX-GM), Brigham and Women's Hospital, Joslin Diabetes Center, UConn Health Center on Aging and Mayo Clinic to characterize cellular senescence in terms of its presence and heterogeneity in healthy human tissues, as well as its tissue burden, spatial distribution, and biological features in a diverse study population.