The Staircase Phenomenon Implications on Neuromuscular Block Monitoring

La Fe University and Polytechnic Hospital

Status: Completed

Conditions: Neuromuscular Blockade Monitoring

Treatments: Device: Tetanus stabilization of baseline

Study type: Interventional

Funder types: Other

Identifiers

NCT03146767

MAZ0816

Details and patient eligibility

About

The staircase phenomenon could have repercussions on the onset and recovery time following administration of a neuromuscular blocking agent. The investigators aim to assess the magnitude of the staircase phenomenon and its impact on various aspects of neuromuscular blockade with a randomized controlled double blind trial.

Enrollment: 50 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ASA (American Society of Anesthesiology surgical risk scale) grade I - II
• Surgery not involving airway performed under general anaesthesia with neuromuscular blocker

Exclusion criteria

• Pregnancy
• BMI (Body Mass Idex) > 35 Kg/m2
• Anticipated difficult airway
• Chronic kidney or hepatic failure
• Neuromuscular disease
• Medication that has known interactions with neuromuscular blockers
• Hemodynamic failure
• Anticipated large blood loss

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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50 participants in 2 patient groups

Tetanic Group

Experimental group

Description:

A Tetanic stimulation (Tetanus stabilization of baseline) is administered to the monitorized arm before calibrating the neuromuscular block monitor. Then Train-of-four (TOF) stimuli are administered every 20 seconds for 20 minutes.

Treatment:

Device: Tetanus stabilization of baseline

Control Group

No Intervention group

Description:

Conventional monitor baseline stabilization: Train-of-four stimuli are administered every 20 seconds for 20 minutes