The Standard Concentration of Morphine as a Positive Control for Intradermal Skin Test

Chulalongkorn University

Status: Completed

Conditions: Intradermal Test

Study type: Observational

Funder types: Other

Identifiers

NCT00853476

Chula-ARC 001/09

Details and patient eligibility

About

This study aims to compare skin reactivity results between morphine and histamine as a positive control agents in intradermal skin test.

Full description

Histamine hydrochloride and different concentrations of morphine sulfate will be intradermally injected and wheal diameter size will be comparatively measured between 15-30 minutes' time points after the test.

Enrollment: 25 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• age 18-60 years old

Exclusion criteria

• immunodeficiency state
• cancer
• severe skin diseases
• severe medical illnesses
• malnutrition
• uncontrolled asthma
• pregnancy
• received oral or systemic corticosteroid within 1 month before this study
• receiving immunosuppressive agents
• taken antihistamine within 3 days before this study
• taking beta-blocker
• previous history of immunotherapy
• have hypersensitivity reaction to morphine/opiates