The Status of Parathyroid Hormone Secretion in Covid-19 Patients

Bezmialem Vakif University

Status: Completed

Conditions: Alkaline Phosphatase; Parathyroid Hormone; Phosphorus; Calcium; COVID-19 Infection; Parathyroid Gland

Treatments: Diagnostic Test: Venous blood was collected for biochemistry testing

Study type: Observational

Funder types: Other

Identifiers

NCT04662437

08122020

Details and patient eligibility

About

COVID-19 infection causes a hypersensitive immune reaction and widespread inflammation in various organs of the body, especially through cytokines in the lungs. This cytokine-mediated widespread inflammation can also affect the parathyroid glands, resulting in impaired parathyroid secretion.

Researchers evaluated the levels of parathyroid hormone, calcium, phosphorus, and alkaline phosphatase in patients hospitalized for COVID-19 infection. Researchers excluded patients on intensive care therapy and patients with known parathyroid disease.

The researchers examined the association of parathyroid hormone secretion with COVID-19 disease, white blood cells, neutrophil / lymphocyte ratio, C reactive protein, fibrinogen, procalcitonin, ferritin, and D-dimer in these patients. The researchers compared the parathyroid hormone level of healthy people without COVID-19 infection and known parathyroid disease with the parathyroid hormone level of Covid-19 patients.

Full description

The coronavirus-2 (SARS-COV-2) virus, which can cause severe acute respiratory syndrome through the droplet, has caused the global Coronavirus 19 (COVID-19) pandemic. COVID-19 infection can be asymptomatic or lead to serious illness and even death. This virus causes a hypersensitive immune reaction and varying degrees of widespread inflammation through cytokines in various organs of the body, mainly the lungs.

Cytokine-mediated widespread inflammation caused by the virus may also affect the parathyroid glands, causing their functions to deteriorate. Thus, it may cause changes in parathyroid hormone secretion.

The researchers evaluated the results of serum parathyroid hormone, calcium, phosphorus, alkaline phosphatase tests in patients who were symptomatic and hospitalized with COVID-19 infection. Participants also evaluated the relationship of parathormone with white blood cells, neutrophil / lymphocyte ratio, c reactive protein, fibrinogen, procalcitonin, ferritin, and D-dimer in these patients. The researchers compared the parathyroid hormone levels of patients with COVID-19 infection with the parathyroid hormone levels of healthy individuals without COVID-19 infection and parathyroid disease. So the investigators looked for differences in parathyroid hormone levels between both groups. Researchers did not include patients in the intensive care unit and patients with known parathyroid disease.

Enrollment: 150 patients

Sex: All

Ages: 18 to 100 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• To accept research.
• Being over the age of 18.
• COVID 19 test results to be positive.
• Not taking parathyroid disease medication before.
• Receiving inpatient treatment in the COVID service in the hospital.

Exclusion criteria

• Not accepting research.
• Be under the age of 18.
• Negative COVID 19 test results for patients.
• COVID patients treated as outpatient.
• Parathyroid disease in the healthy control group.

Trial design

150 participants in 2 patient groups

Covid-19 Patient Group

Description:

10 ml of venous blood was taken from the forearm venous vein from people in the Covid-19 Patient Group, and the level of parathyroid hormone, calcium, phosphorus, alkaline phosphatase was measured from this blood.

Treatment:

Diagnostic Test: Venous blood was collected for biochemistry testing

Healthy Control Group

Description:

10 ml of venous blood will be taken from the forearm venous vein from the healthy control group and the parathyroid hormone, calcium, phosphorus, alkaline phosphatase level will be measured from this blood.

Treatment:

Diagnostic Test: Venous blood was collected for biochemistry testing