The Stockholm Sleepy Brain Study: Effects of Sleep Deprivation on Cognitive and Emotional Processing in Young and Old

Mats Lekander

Status: Completed

Conditions: Sleep Deprivation

Treatments: Behavioral: Partial sleep deprivation allowing 3 h sleep at night; Behavioral: Full sleep

Study type: Interventional

Funder types: Other

Identifiers

NCT02000076

Sleepy Brain Study Wave 1

Details and patient eligibility

About

The main purpose of this study is to investigate the effects of partial sleep deprivation (PSD) on resting state brain connectivity, emotional contagion, empathy, and emotional regulation.

Enrollment: 98 patients

Sex: All

Ages: 20 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 20-30 years of age, inclusive OR 65-75 years of age, inclusive

• Able to understand spoken and written Swedish (in order to understand instructions)

• Normal or corrected-to-normal vision not using glasses

• Not colour blind

• Right-handed

• Free from ferromagnetic objects in body

• No history of any neurologic or psychiatric illness including drug abuse

• No history of diabetes nor hypertension

  • No depression according to ratings using the Hospital Anxiety and Depression scale (HAD)
  • No insomnia according to ratings using the Insomnia Severity Index (ISI) and Karolinska Sleep Questionnaire (KSQ)

• No use of psychotropic drugs

• Not studying or working in medicine, psychology, nor behavioural science

• Not suffering from severe seasonal allergy

• No use of cortisone, anti-histamines, nor any other immune-modulating drugs

• Habitual intake of no more than 4 cups of coffee per day or the equivalent in terms of caffeine

• No daily use of nicotine

Exclusion criteria

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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98 participants in 2 patient groups

Sleep deprivation

Experimental group

Description:

Partial sleep deprivation allowing 3 h sleep at night

Treatment:

Behavioral: Partial sleep deprivation allowing 3 h sleep at night

Full sleep

Experimental group

Description:

Sleep with no restriction

Treatment:

Behavioral: Full sleep