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This study uses to suppress the growth of tumors, extend the patient's survival time and improve the quality of life as much as possible. Through the treatment, the patient is given the chance to undergo surgical resection, thereby more effectively prolonging the OS. Apatinib is a small-molecule VEGFR tyrosine kinase inhibitor. It mainly treats malignant tumors by inhibiting VEGFR and exerting anti-angiogenic effects. Preclinical studies have shown that its anti-tumor effect is better than that of the similar drug PTK787. Phase II studies of hepatocellular carcinoma have initially demonstrated the effectiveness and safety of apatinib in the treatment of advanced HCC. Radiotherapy of tumors and portal vein tumor thrombi can promote further tumor shrinkage, and at the same time, the physiological basis for the recanalization of the original tumor thrombus itself will result in necrosis and fibrosis of the tumor thrombus, completely blocking the blood supply to the tumor portal vein. As a result, blood supply to the other side of the portal vein increases, and hepatocyte regeneration in a healthy liver is promoted, so that the patient can obtain surgical opportunities. Based on the therapeutic potential of apatinib and radiotherapy, we designed a prospective exploratory clinical study of this patient with advanced liver cancer.
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Inclusion criteria
Age: ≥18 years old;
An unresectable HCC patient who is in strict compliance with the criteria for diagnosis and treatment of primary liver cancer (2011 edition) or who has been diagnosed by pathological or cytological examination and has at least one measurable lesion;
Child-Pugh Liver Function Rating: Grade A or better Grade B (≤ 7 points);
Cheng's type I and type II (imaging evaluation of the tumor portal vein tumors did not reach the contralateral portal vein branch, and embolization does not exceed 50% of the portal vein diameter) PVTT BCLC-C patients;
Clinical evaluation cannot tolerate radical surgical resection;
The tumor is confined to the hepatic liver;
The first patient who had not received any anti-cancer comprehensive treatment before;
ECOG PS score: 0-1 points;
The expected survival period is ≥ 3 months;
The normal function of the major organs is the following:
Blood tests:
Biochemical tests:
Subjects voluntarily joined the study and signed informed consent. Good compliance and follow-up.
Exclusion criteria
Primary purpose
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Interventional model
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50 participants in 2 patient groups
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Data sourced from clinicaltrials.gov
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