The Study of EIT-guided Ventilation Strategy on ARDS Patients

Chinese Academy of Medical Sciences & Peking Union Medical College

Status: Unknown

Conditions: Pulmonary Perfusion; ARDS

Treatments: Procedure: EIT-guided PEEP setting; Procedure: ARDS-net PEEP setting

Study type: Interventional

Funder types: Other

Identifiers

NCT04734340

EIT-RCT

Details and patient eligibility

About

This study is a clinical randomized controlled study.The objective of this study is to compare the prognosis of patients with ARDS between eit-v / q-oriented individualized ventilation strategy and traditional lung protection ventilation strategy, and to establish the demonstration application of eit-v / q-oriented ventilation strategy in ARDS

Enrollment: 100 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. According to ARDS Berlin standard, ARDS, PaO2 / FiO2 < 200mmhg, peep > 5cmh2o;
2. According to clinical judgment, lung recruitment therapy is needed due to hypoxemia;
3. The subjects or their families signed informed consent.
4. Admission to ICU was less than 72 hours;
5. The estimated duration of mechanical ventilation was more than or equal to 48 hours;
6. Age ≥ 18 years old and ≤ 80 years old;

Exclusion criteria

1. The patients with heart implants could not be monitored by EIT;
2. Patients or their families refused to participate in the study;
3. Hypernatremia

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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100 participants in 2 patient groups, including a placebo group

EIT-guided group

Experimental group

Description:

Treatment based on EIT

Treatment:

Procedure: EIT-guided PEEP setting

Control group

Placebo Comparator group

Description:

Treatment based on ARDS-net Peep setting

Treatment:

Procedure: ARDS-net PEEP setting