The Study of Gut Microbiota in Hypertensive Patients

Taipei Medical University

Status: Invitation-only

Conditions: Hypertension; Gut Microbiota; Diet

Study type: Observational

Funder types: Other

Identifiers

NCT05057039

CGH-P110063

Details and patient eligibility

About

Recent animal and human studies have found the relationship between the composition of the gut microbiota and hypertension, but some studies did not have a detailed evaluation of the diet content, which could be an important effect on gut microbiota. Moreover, most of these studies were finished in Western countries, in which the dietary patterns were significantly different from those in Chinese regions. This study intends to establish Taiwanese local data to explore the differences in the composition of gut microbiota among hypertensive patients and normotensive subjects.

Full description

The investigators plan to enroll total 70 hypertensive and normotensive cases from the elderly health examination in Cathay General Hospital, who are aged from 65 to 80 years. Body mass index and blood samples for biochemical analysis such as blood sugar and cholesterol levels are taken, and fecal samples are collected for analysis of gut microbiota, which is characterized by 16S ribosomal RNA gene sequencing. Besides, the diet and nutrients intake are recorded and calculated by licensed dietitian. Through the exploration of gut microbiota in hypertensive patients, the results can be the reference for clinical treatment.

Enrollment: 70 estimated patients

Sex: All

Ages: 65 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Age 65~80 years old
2. People who join the Elderly Health Examination Program in Cathay General Hospital in 2021

Exclusion criteria

1. Antibiotics use within one month
2. Acute gastrointestinal illness within one week, such as vomiting and diarrhea
3. History of gastrointestinal surgery
4. History of inflammatory bowel disease
5. Chronic gastrointestinal disease under medication treatment
6. Cannot finish dietary record

Trial design

70 participants in 2 patient groups

hypertensive group

Description:

SBP \>=140mmHg, DBP \>=90mmHg, or use of antihypertensive drug

normotensive group

Description:

SBP \<=140mmHg and DBP \<=90mmHg without use of antihypertensive drug