The Study of Lithogenesis Processes in Patients With Non-alcoholic Fatty Liver Disease (NAFLD) (LINA)

Institute of Hospitalization and Scientific Care (IRCCS)

Status: Completed

Conditions: Urinary Lithiasis; NAFLD

Study type: Observational

Funder types: Other

Identifiers

NCT06357052

2701

Details and patient eligibility

About

Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease, ranging from pure steatosis to non-alcoholic steatohepatitis and ultimately to liver cirrhosis. In order to study the association between NAFLD and nephrolithiasis while minimizing the confounding effect of metabolic syndrome, we investigated the impact of different degrees of NAFLD severity on potential risk factors for stone formation.

Enrollment: 42 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• subject >= 18 years old
• able to sign the ICF
• Liver biopsy with report compatible with NAFLD

Exclusion criteria

• alchol use > 20g/die
• other causes of liver disease
• active neoplasm

Trial design

42 participants in 3 patient groups

NAFLD patients without liver cirrhosis (NLCs, n = 28)

NAFLD patients with liver cirrhosis (LCs, n = 14)

healthy individuals (HIs, n = 12)