The Study of Mechanism of Alzheimer's Disease Using Acupuncture Based on fMRI

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Capital Medical University

Status

Unknown

Conditions

Alzheimer's Disease

Treatments

Procedure: true acupuncture
Procedure: sham acupuncture

Study type

Interventional

Funder types

Other

Identifiers

NCT02759159
81471649

Details and patient eligibility

About

Alzheimer's disease (AD) is one of the major brain diseases which received more attention in recent years. The disconnection syndrome is the main pathophysiological mechanism leading to cognitive decline in AD patients. Both animal experiment and clinical observation have demonstrated that acupuncture can generate treatment effect on AD patients by moderating the neural pathway directly. However, the underlying mechanism remains unclear. By using resting state functional magnetic resonance imaging (fMRI) method, as well as acupuncture and neurology sciences, investigators will explore the multi-modality data analysis; compare brain connectivity and network parameters changes between pre- and post- acupuncture treatment; analyze the correlation between fMRI changes and neuropsychology test. The present study aims to elucidate the neural mechanism of acupuncture therapy on early AD, provide theoretical evidence from the perspective of functional connectivity.

Enrollment

120 estimated patients

Sex

All

Ages

50 to 85 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Clinical diagnosis of Alzheimer's Disease Clinical diagnosis of MCI due to Alzheimer's Disease Drug therapy regularly

Exclusion criteria

Frontotemporal dementia Lewy body dementia Vascular dementia Severe depression Brain vascular disease Metabolic disease

Trial design

Primary purpose

Basic Science

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Triple Blind

120 participants in 4 patient groups

AD-true acupuncture
Experimental group
Description:
True acupuncture at the "four-gate"acupoints will be administered on AD patients
Treatment:
Procedure: true acupuncture
AD-sham acupuncture
Sham Comparator group
Description:
Sham acupuncture at the "four-gate"acupoints will be administered on AD patients
Treatment:
Procedure: sham acupuncture
Mild Cognitive Impairment(MCI)-true acupuncture
Experimental group
Description:
True acupuncture at the "four-gate"acupoints will be administered on MCI patients
Treatment:
Procedure: true acupuncture
MCI-sham acupuncture
Sham Comparator group
Description:
Sham acupuncture at the "four-gate"acupoints will be administered on MCI patients
Treatment:
Procedure: sham acupuncture

Trial contacts and locations

2

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Central trial contact

Hui Li; Kuncheng Li, Doctor

Data sourced from clinicaltrials.gov

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