The Study of Using Esophageal Pressure to Guide the PEEP Setting in Abdominal Hypertension Patients Who Undergoing Mechanical Ventilation

Nanjing Medical University

Status and phase: Unknown; Phase 4

Conditions: Intra-abdominal Hypertension; ARDS

Treatments: Device: titrated setting peep

Study type: Interventional

Funder types: Other

Identifiers

NCT01825304

CC110-92

Details and patient eligibility

About

Intra-abdominal hypertension can increase the pleural pressure, and then end-expiratory transpulmonary pressures will be turn to negative, Pulmonary atelectasis/acute lung injury/acute respiratory distress syndrome will appear. In the group of people who suffering intra-abdominal hypertension, the investigators use the pressure of esophagus to speculate the Intrathoracic pressure, and to setting PEEP in order to decrease the happening of ALI/ARDS, which may decrease morbidity in this population.

Enrollment: 60 estimated patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• intra-abdominal hypertension
• mechanical ventilation
• sedation

Exclusion criteria

• underlying pulmonary disease
• age older than 60 years and younger than 18 years
• vital signs were not stable
• non voluntary

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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60 participants in 2 patient groups

esophageal pressure ,titrated setting

Active Comparator group

Treatment:

Device: titrated setting peep

ARDSNet recommendations,peep

Other group

Treatment:

Device: titrated setting peep