The Study on Effects of Acute Exposure to High Altitude Hypoxia on Cognitive Function in Lowlanders

Air Force Military Medical University of People's Liberation Army

Status: Completed

Conditions: Cognition

Study type: Observational

Funder types: Other

Identifiers

NCT05411185

KY20222059

Details and patient eligibility

About

The purpose of this study is to investigate the impact of rapid elevation to 3,800 meters on the cognitive function of low-altitude residents through a plateau field and plain control study, and explore the objective indicators related to the impaired cognitive function.

Full description

This study intends to recruit 60 healthy young people residing in plain area to 3000 m. Participants were divided into two groups: the plateau group (N=30) and the plain group (N=30).

Firstly, we collected baseline data one week before the plateau group rushed to the plateau, and then repeated the above data collection at the same time on day 1 (3-5 hours after arrival), day 2, day 3, day 5, and day 7 after entering the plateau. The plain group was studied in the plain according to the same test plan.

Finally, analyze and find out the main types of cognitive impairment, and explore the physiological prediction index, including exploring the characteristics of EEG changes before and after entering the plateau.

Enrollment: 43 patients

Sex: All

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Lived in plain, never entered the plateau

Exclusion criteria

• patients with epilepsy, migraine, brain injury, stroke and other neuropsychiatric diseases;
• central nervous system drugs;
• history of heart or head surgery;
• MMSE score < 25;
• patients suffering from pulmonary heart disease, chronic obstructive pulmonary disease, emphysema, pulmonary embolism and other serious respiratory diseases;
• patients with negative resistance to the study and poor compliance.

Trial design

43 participants in 2 patient groups

the plateau group

Description:

People travelling from the plains to areas at altitudes of 3800 meters

the plain group

Description:

People staying in the plains throughout the whole test