The Synergistic Effects of Menopause and HIV on Cardiovascular Disease Risk in Women

University of California San Francisco (UCSF)

Status: Not yet enrolling

Conditions: Cardiovascular (CV) Risk; Menopause; HIV; Carotid Arteriosclerosis; Body Composition

Treatments: Diagnostic Test: Whole body MRI

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT07284082

K23HL178394 (U.S. NIH Grant/Contract)

25-43802

Details and patient eligibility

About

Menopause is associated with the acceleration of many comorbidities, including cardiovascular disease. Whether HIV and menopause together increase cardiovascular disease risk is a key knowledge gap. The goal of this observational study is to address this knowledge gap by looking at the role of menopause on cardiovascular disease risk factors such as insulin resistance, hypertension, hyperlipidemia, and carotid atherosclerosis using previously collected data. The investigators will look at underlying causes for cardiovascular diseases worsening in menopausal women with HIV by looking at the role of increased inflammation in the body and whether this is altered by weight. The investigators achieve this by enrolling participants who are willing to undergo a whole body MRI.

Enrollment: 90 estimated patients

Sex: Female

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 90 non-pregnant women with HIV (approximately 30 in each menopausal phase) from the San Francisco MWCCS site.

Exclusion criteria

• Women who are not virally suppressed (HIV RNA >200 copies/mL)
• Women who are not on antiretroviral therapy
• Women who have a history of hysterectomy or oophorectomy
• Women who are receiving treatment for active cancer or tuberculosis

Trial design

90 participants in 1 patient group

MACS-WIHS Combined Cohort Study

Treatment:

Diagnostic Test: Whole body MRI