The Synergistic Metastases Annihilation With Radiotherapy and Docetaxel (Taxotere) [SMART] Trial for Non-Small Cell Lung Cancer (NSCLC)

The University of Chicago

Status and phase

Terminated

Phase 2

Conditions

Non-small Cell Lung Cancer

Treatments

Drug: Docetaxel and cisplatin

Radiation: Docetaxel and cisplatin Plus Hypofractionated Radiotherapy

Study type

Interventional

Funder types

Other

Identifiers

NCT00887315

16574B

Details and patient eligibility

About

Primary goal of the study is to assess the overall survival of the addition of hypofractionated image guided radiotherapy concurrently with Docetaxel and cisplatin. Survival will be assessed at 1 year from the date of study enrollment to date of death.

Enrollment

11 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Age 18 years or older
Life expectancy > 6 months
Histologically or cytologically confirmed diagnosis of NSCLC
Patients with AJCC stage IV cancer with distant metastases and without malignant pleural or pericardial effusion at diagnosis and before start of study
1. Patients with pleural effusion that is transudative, cytologically negative, and non-bloody are eligible as long as they are stable and do not impair the ability to define tumor volumes.
2. If a pleural effusion is too small for diagnostic thoracentesis, the patient will be eligible.
Primary and regional nodal disease that is encompassable in a reasonable radiotherapy portal:
Patients with 1-5 sites of disease and amenable to RT therapy as seen on standard imaging (CT, MRI, bone scan, PET scan)
Unidimensionally measurable disease (based on RECIST) is desirable but not strictly required.
Patients with brain metastases are allowed as long as they meet all other inclusion criteria. Brain metastases must be treated with whole brain radiotherapy and stereotactic radiosurgery or surgical resection followed by whole brain radiotherapy.
ECOG performance status <2
No prior RT to currently involved tumor sites
Baseline peripheral neuropathy < grade 1
Room air saturation (SaO2) > 90%
Patients must have normal organ and marrow function
Men and women of childbearing potential must be willing to consent to using effective contraception while on treatment and for at least 3 months thereafter.
Signed Informed consent
Inclusion of Women and Minorities
RT: Patient must have a completed treatment plan approved by the protocol review team

Exclusion criteria

Uncontrolled intercurrent illness including, but not limited to, ongoing active infection, symptomatic congestive heart failure (CHF), unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with the study requirements
Patients with clinically significant pulmonary dysfunction, cardiomyopathy, or any history of clinically significant CHF are excluded. The exclusion of patients with active coronary heart disease will be at the discretion of the attending physician.
Patients with significant atelectasis such that CT definition of the gross tumor volume (GTV) is difficult to determine.
< 1000 cc of tumor free lung.
Tumor volume and location which requires a lung volume-PTV >40% to receive >20 Gy (V20 <40%).
Patients with exudative, bloody, or cytologically malignant effusions are not eligible.
Pregnancy or breast feeding (Women of child-bearing potential are eligible, but must consent to using effective contraception during therapy and for at least 3 months after completing therapy)
Patients must have no uncontrolled active infection other than that not curable without treatment of their cancer.
Patients with a history of severe hypersensitivity reaction to docetaxel or other drugs formulated with polysorbate 80.
Patient may not be receiving any other investigational agents.