The Telomere System in Cord Blood and in the Placenta in High Risk Pregnancies

Clalit Health Services

Status: Unknown

Conditions: Telomere Length; Mechanisms of Telomter Homeostasis; High Risk Pregnancies

Study type: Observational

Funder types: Other

Identifiers

NCT01384136

036-2011 MMC

Details and patient eligibility

About

The telomere system stabilizes the chromosomes. Telomeres are shortened during senescence, in cases of genetic instability and secondary to stress.

The investigators aim is to study the telomere system in cord blood and in the placenta immediately after the delivery in pregnancies defined as high risk pregnancies following sterss events such as placental insufficiency, preeclampsia, diabetes.

The investigators intend to compare the telomere system in maternal blood to cord blood and to placental biopsies and to study the influence of different stressogenes on this system.

Enrollment: 100 estimated patients

Sex: Female

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Third trimester post delivery
• Intrauterine growth restriction
• Preeclampsia
• Diabetes
• Control - low risk normal pregnancies

Exclusion criteria

• Patients who do not want to participate
• Known HIV or Hepatitis

Trial design

100 participants in 2 patient groups

High risk pregnancy

|Control - Normal low risk pregnancies