The Therapeutic Effects of Continuous Theta Burst Stimulation in Autism Spectrum Disorder

Chang Gung Medical Foundation

Status: Enrolling

Conditions: Autism Spectrum Disorder

Treatments: Device: continuous theta burst stimulation

Study type: Interventional

Funder types: Other

Identifiers

NCT04993144

201802246A0

Details and patient eligibility

About

The investigator would like to investigate the impact of theta burst stimulation over left dorsolateral prefrontal cortex in autism spectrum disorder

Enrollment: 90 estimated patients

Sex: All

Ages: 8 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• autism spectrum disorder, confirmed by ADOS

Exclusion criteria

• current and past systemic disease
• current and past major psychiatric disorders including schizophrenia, bipolar affective disorder and major depressive disorder
• current and past brain injuries
• intelligence < 70
• seizure history
• pregnant

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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90 participants in 3 patient groups

Active

Active Comparator group

Description:

Participants received the real intervention of TBS (cTBS 600) over the left dorsolateral prefrontal cortex for 8 weeks (2 days/week). \*cTBS = continuous theta burst stimulation

Treatment:

Device: continuous theta burst stimulation

Sham

Sham Comparator group

Description:

Participants received the sham intervention of TBS (coil tilted one-wing 90° off the head) over the left dorsolateral prefrontal cortex for 8 weeks (2 days/week).

Treatment:

Device: continuous theta burst stimulation

Normal control

No Intervention group

Description:

No intervention.