The Therapeutic Effects of Intermittent Theta Burst Stimulation in Autism Spectrum Disorder

Chang Gung Medical Foundation

Status: Enrolling

Conditions: Autism Spectrum Disorder

Treatments: Device: intermittent theta burst stimulation

Study type: Interventional

Funder types: Other

Identifiers

NCT04987749

201900713A0

Details and patient eligibility

About

The investigator would like to investigate the impact of theta burst stimulation over right inferior frontal gyrus in autism spectrum disorder

Enrollment: 60 estimated patients

Sex: All

Ages: 8 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• autism spectrum disorder, confirmed by ADOS

Exclusion criteria

• current and past systemic disease
• current and past major psychiatric disorders including schizophrenia, bipolar affective disorder and major depressive disorder
• current and past brain injuries
• intelligence < 70
• seizure history
• pregnant

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

---

60 participants in 2 patient groups

Active

Active Comparator group

Description:

Participants received the real intervention of TBS (iTBS 600) over the right inferior frontal gyrus for 8 weeks (2 days/week). \*iTBS = intermittent theta burst stimulation

Treatment:

Device: intermittent theta burst stimulation

Sham

Sham Comparator group

Description:

Participants received the sham intervention of TBS (coil tilted one-wing 90° off the head) over the right inferior frontal gyrus for 8 weeks (2 days/week).

Treatment:

Device: intermittent theta burst stimulation