The Therapeutic Time Window of Mannitol During Craniotomy for Optimal Brain Relaxation in Patients With Supratentorial Tumours

Fudan University

Status: Completed

Conditions: Supratentorial Tumors

Treatments: Drug: Mannitol

Study type: Interventional

Funder types: Other

Identifiers

NCT03444519

KY2017-306

Details and patient eligibility

About

Although mannitol is used for brain relaxation during neurosurgery and in the treatment of raised intracranial pressure; there is not a consensus on its safe, effective dose and the duration of its administration. This study aimed to compare the effects of the mannitol in different use times, on the brain relaxation, electrolyte, lactate levels of the blood, peroperative fluid balance and the volume of the urine in supratentorial mass resection surgeries.

Enrollment: 100 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Intracranial shift >3mm
• Scheduled for supratentorial mass resection under elective conditions

Exclusion criteria

• Decompensated heart failure
• kidney insufficiency
• Diabetes insipidus,
• Electrolyte imbalance and
• Who are unconscious

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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100 participants in 2 patient groups

Mannitol A

Experimental group

Description:

in this group, Mannitol (1.0g/kg) is given just after the induction of general anesthesia

Treatment:

Drug: Mannitol

Mannitol B

Active Comparator group

Description:

in this group, Mannitol (1.0g/kg) is given at the time of skin incision

Treatment:

Drug: Mannitol