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The Three-dimensional Gait Analysis of Medial Knee Osteoarthritis

G

Guangzhou General Hospital of Guangzhou Military Command

Status

Completed

Conditions

Osteoarthritis
Osteoarthritis, Knee

Treatments

Other: Steps 2
Other: Steps 1

Study type

Observational

Funder types

Other

Identifiers

NCT02878239
GuangzhouGH001

Details and patient eligibility

About

Static imaging has been commonly and clinically accepted to assess the severity of medial knee osteoarthritis (KOA), especially the radiography. Gait analysis has been adopted to evaluate the kinematic characteristics of the knees in patients with KOA. Most of the current studies focus on the sagittal plane of the knee, but very few of them focus on the frontal or horizontal plane. With the different severity of medial KOA, anatomical structures of the knees will change and influence kinematics of the knees, such as osteophytes and deformity. At present, there has been no study focusing on the relations between the imaging assessment of the severity and quantitative kinematics of medial KOA. The aim of the study is to explore the relationship between the imaging assessment based on the Kellgren-Lawrence Scores and in vivo 3D knee kinematic characteristics in Chinese patients with medial KOA during walking using a new portal gait system.

Full description

All patients are assessed according to the Kellgren-Lawrence Score.

Enrollment

136 patients

Sex

All

Ages

35 to 80 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  1. Clinical diagnosis of medial knee osteoarthritis according to the American College of Rheumatology criteria.
  2. The patients are confirmed by radiographic evidence that medial tibiofemoral joint space grade was narrower than lateral tibiofemoral joint space.
  3. The patients have clinical symptom of medial pain of the knee.
  4. Clinical examinations are taken to examine the asymptomatic subjects to avoid knee diseases.

Exclusion criteria

  1. Traumatic knee osteoarthritis.
  2. Lateral tibiofemoral KOA or any other types of Knee OA.
  3. Ambiguity of Kellgren-Lawrence scores
  4. History of surgery.
  5. Neuromuscular disease, cardiovascular disease or trauma that can affects gait.
  6. Body mass index greater than 35.
  7. Needing stick or assistance to walk or unable to walk at a speed of less than 2.0 km/h and less than 300 m.

Trial design

136 participants in 4 patient groups

Early OA
Description:
All patients (>35 years) have been diagnosed with medial knee osteoarthritis according to the American College of Rheumatology criteria. Those are classified as patients with early knee osteoarthritis because their Kellgren-Lawrence Scores were Grade I.
Treatment:
Other: Steps 1
Moderate OA
Description:
All patients (>35 years) have been diagnosed with medial knee osteoarthritis according to the American College of Rheumatology criteria. Those are classified as patients with moderate knee osteoarthritis because their Kellgren-Lawrence Scores were Grade II.
Treatment:
Other: Steps 1
Severe OA
Description:
All patients (>35 years) have been diagnosed with medial knee osteoarthritis according to the American College of Rheumatology criteria. Those are classified as patients with moderate knee osteoarthritis because their Kellgren-Lawrence Scores were Grade III/IV.
Treatment:
Other: Steps 1
Asymptomatic Participants
Description:
The asymptomatic participants(>35 years) has no history of knee pain, trauma, surgery, or obvious gait abnormalities. They are set as controls in the study.
Treatment:
Other: Steps 2

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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