The Time of Positive Conversion of Interferon-γ Releasing Assay After Tuberculosis Exposure

Armed Forces Capital Hospital, Republic of Korea

Status: Completed

Conditions: Tuberculosis

Study type: Observational

Funder types: Other

Identifiers

NCT00981071

QFTconversion

Details and patient eligibility

About

The aim is to evaluate the time of positive conversion after exposure to smear positive pulmonary tuberculosis (TB) in a platoon of Korean military, a closed communal setting.

Full description

In a platoon where TB outbreak occurred, we performed low dose chest CT (LDCT), QuantiFERON-TB gold in tube (QFT) and two-step (0, 4weeks) TST for outbreak investigation. We perform QFT at 0, 2, 4, 8 and 12 weeks after initial investigation for soldiers with negative QFT results, and soldiers with positive QFT and normal LDCT took isoniazid and rifampin for 3 months as treatment of latent TB.

Enrollment: 32 patients

Sex: Male

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• All soldiers who assigned to the military platoon where a tuberculosis outbreak occurred

Exclusion criteria

• Soldiers who could not complete study or refused the study protocol

Trial design

32 participants in 1 patient group

A platoon with TB outbreak