The Transcriptomic Study of Thai Patients With Atopic Dermatitis by Tape Strips

Queen Sirikit National Institute of Child Health

Status: Not yet enrolling

Conditions: Atopic Dermatitis

Treatments: Genetic: Tape strips

Study type: Interventional

Funder types: Other

Identifiers

NCT05598762

65-007

Details and patient eligibility

About

This study will be use the tape strip technique to evaluate the skin biomarkers of atopic dermatitis among Thai patients to differentiate clinical phenotype.

Full description

The patients will be enrolled in this study if they have been diagnosed with atopic dermatitis. All participants (AD patients and controls) will be evaluated their skin biomarkers by using tape stripping. The tape strips will be applied to the antecubital fossa to collect the epithelial samples. Then RNA was extracted from the tape strips for mRNA profiling to identify the immune and epidermal barrier genes.

Enrollment: 100 estimated patients

Sex: All

Ages: 1 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Children (age 1-18 years old) with mild atopic dermatitis
• Children (age 1-18 years old) with moderate to severe atopic dermatitis
• Children (age 1-18 years old) with moderate to severe atopic dermatitis and food allergy
• Adult (age 18-60 years old) with atopic dermatitis
• Healthy individuals (1-60 years old)
• Patients with asthma (1-60 years old)

Exclusion criteria

• Active skin infections
• Used systemic immunosuppressants within 4 weeks
• Used topical steroids or immunomodulators within 1 week
• Used moisturizers within 12 hours before evaluation

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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100 participants in 6 patient groups

Children with mild atopic dermatitis

Active Comparator group

Description:

* age 1-8 years old * mild degree of atopic dermatitis

Treatment:

Genetic: Tape strips

Children with moderate-severe atopic dermatitis

Active Comparator group

Description:

* age 1-8 years old * moderate or severe degree of atopic dermatitis

Treatment:

Genetic: Tape strips

Children with food allergy and moderate-severe atopic dermatitis

Active Comparator group

Description:

* age 1-8 years old * moderate or severe degree of atopic dermatitis * IgE mediated food allergy

Treatment:

Genetic: Tape strips

Adult with atopic dermatitis

Active Comparator group

Description:

* age 18-60 years old * mild-severe atopic dermatitis

Treatment:

Genetic: Tape strips

Healthy

Active Comparator group

Description:

* age 1-60 years old * no history of atopic diseases

Treatment:

Genetic: Tape strips

Healthy with Asthma

Active Comparator group

Description:

* age 1-8 years old * doctor diagnosed asthma * no history of chronic or chronic relapsing eczema

Treatment:

Genetic: Tape strips