The Transition From Blastomere to Trophectoderm Biopsy: Comparing Two PGS Strategies

I

Institut Universitari Dexeus

Status

Completed

Conditions

Infertility
Preimplantation Genetic Screening

Treatments

Procedure: Trophectoderm biopsy group
Procedure: Cleavage stage biopsy group

Study type

Observational

Funder types

Other

Identifiers

NCT03062969
FDS-PGS-01

Details and patient eligibility

About

Shortly after the implementation of Comprehensive Chromosome Screening (CCS) techniques for Preimplantation Genetic Screening (PGS) came the transition in biopsy timing. Trophectoderm biopsy is meant to overcome the limitations of cleavage stage biopsy and single cell analysis.

Full description

The investigators have recently introduced this new approach and a frozen-thawed policy of euploid blastocysts is routinely performed. This is a single centre retrospective study in patients undergoing a PGS cycle. The aim of the study is to assess the results obtained in a PGS programme after the implementation of a new biopsy timing and transfer policy. Results obtained in PGS cycles with blastocyst biopsy and frozen-thawed embryo transfer were analysed in comparison to cycles with cleavage stage biopsy and fresh blastocyst transfer.

Enrollment

383 patients

Sex

Female

Ages

18 to 45 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Own gametes
  • PGS for: advanced maternal age, repeated implantation failure, recurrent miscarriages, severe male factor, and previous affected pregnancies

Exclusion criteria

  • PGS cycles with gamete donation
  • Altered karyotypes
  • Combined Preimplantation genetic diagnosis (PGD)+PGS cycles

Trial design

383 participants in 2 patient groups

Cleavage stage biopsy group
Description:
Patients undergoing a PGS cycle with single blastomere biopsy on day 3 and analysis using comparative genomic hybridation bacterial artificial chromosome (BAC) arrays (aCGH) If euploid blastocysts were available, patients underwent fresh blastocyst transfer on day 5.
Treatment:
Procedure: Cleavage stage biopsy group
Trophectoderm biopsy group
Description:
Patients undergoing a PGS cycle with blastocyst biopsy on day 5-7 and analysis using comparative genomic hybridation bacterial artificial chromosome (BAC) arrays (aCGH). If euploid blastocysts were available, patients underwent frozen-thawed blastocyst transfer.
Treatment:
Procedure: Trophectoderm biopsy group

Trial contacts and locations

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Data sourced from clinicaltrials.gov

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