The Treatment of Magnesium Sulfate and Nifedipine in Preterm Labor Threat (MgSO4)

Konya Meram State Hospital

Status: Enrolling

Conditions: Pregnancy Preterm; Preterm Labor Without Delivery

Treatments: Drug: Nifedipine; Drug: Magnesium sulfate

Study type: Interventional

Funder types: Other

Identifiers

NCT05520021

351507

Details and patient eligibility

About

Comparison of the effects of Nifedipine and MgSO4 therapies on maternal and fetal blood flow.

Full description

In this study, the investigators aim to compare the effect of Nifedipine and MgSO4 therapies on Doppler parameters of the uterine, umbilical, middle cerebral arteries, and ductus venous in the first 48 hours of therapy in pregnancies with preterm labor threat and also compare perinatal outcomes after delivery between the groups.

Enrollment: 30 estimated patients

Sex: Female

Ages: 18 to 38 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• pregnancies with preterm labor threat between 28-34 weeks gestational ages

Exclusion criteria

• Cervical dilatation at > 4 cm and/or cervical effacement >80%,
• Multiple pregnancies,
• Pregnancy complications including preeclampsia, ablatio placenta, intrauterine growth restriction, placenta previa, gestational diabetes

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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30 participants in 3 patient groups

Magnesium sulfate treatment

Active Comparator group

Description:

A total of 30 pregnancies with preterm labor threats will be treated with Magnesium sulfate.

Treatment:

Drug: Magnesium sulfate

Nifedipine treatment

Active Comparator group

Description:

A total of 30 pregnancies with preterm labor threats will be treated with Nifedipine.

Treatment:

Drug: Nifedipine

Healthy pregnant women

No Intervention group

Description:

A total of 30 pregnancies without preterm labor threat will be included.