The TRIple Elimination Model Of Mother-to-child Transmission Program (TRI-MOM)

French Public Scientific and Technological Institution (EPST)

Status: Enrolling

Conditions: Syphilis; HBV; Hiv

Treatments: Other: TRI-MOM intervention

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT05951751

IRD_2023_SESSTIM_TRI-MOM

Details and patient eligibility

About

The TRI-MOM program aims to implement and evaluate a simplified (based on inexpensive rapid diagnostic tests), integrated (in governmental health facilities) and coordinated (between health care workers) strategy for the triple elimination of HIV, syphilis and HBV mother-to-child transmission (MTCT) in nine maternal and child health services, 5 in Burkina Faso and 5 in The Gambia.

The TRI-MOM program has two components:

1. an "intervention" component consisting of a pilot study to reinforce the antenatal screening and prevention of MTCT (PMTCT) capacities for the 3 targeted infections through the implementation of a simplified, integrated and coordinated strategy of triple elimination of MTCT.
2. an "evaluation" component which will assess the impact of the TRI-MOM strategy on PMTCT services, reduction of HBV MTCT and women empowerment.

Full description

The TRI-MOM (TRIple elimination Model Of Mother-to-child transmission of HIV/Syphilis and HBV in Burkina Faso and The Gambia) program aims to implement and evaluate a simplified (based on inexpensive rapid diagnostic tests), integrated (in governmental health facilities) and coordinated (between health care workers) strategy for the triple elimination of HIV, syphilis and HBV MTCT in nine maternal and child health services, 5 in Burkina Faso and 5 in The Gambia. In The Gambia, the program will be conducted in collaboration with the national HIV, sexually transmitted infections (STI) and hepatitis programmes.

The TRI-MOM program has two components:

1. an "intervention" component consisting of a pilot study to reinforce the antenatal screening and PMTCT capacities for the 3 targeted infections through the implementation of a simplified, integrated and coordinated strategy of triple elimination of MTCT. This pilot study will be conducted in 9 selected maternities.
2. an "evaluation" component which will assess the impact of the TRI-MOM strategy on PMTCT services, reduction of HBV MTCT and women empowerment.

Intervention component :

The TRI-MOM strategy includes 4 main activities:

1. Training of healthcare professionals in charge of maternal health (nurses, midwives and doctors in charge of maternal health services)
2. Triple screening of HIV, Syphilis and HBV by rapid diagnostic tests
3. Assessment and treatment of women positive for any of the 3 targeted infections
4. Raising awareness on MTCT among pregnant women visiting antenatal services and empowering women infected with at least one of the three infections

Evaluation component :

The TRI-MOM program will include three studies :

1. A quantitative and qualitative cross-sectional study before and after the implementation of the strategy.
2. A cohort study of pregnant women positive for any of the three infections.
3. Cost and cost-effectiveness analysis.

Enrollment: 2,800 estimated patients

Sex: Female

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Women attending a postnatal visit in one of the selected maternities (no maternal age limit)

Exclusion criteria

• Refusal to participate in the study
• Unable to provide consent

Trial design

Primary purpose: Health Services Research

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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2,800 participants in 1 patient group

TRI-MOM

Experimental group

Description:

Women attending their first postnatal visit in one of the selected maternities (no maternal age limit) will be eligible to participate in the study

Treatment:

Other: TRI-MOM intervention