The University of Hong Kong Neurocognitive Disorder Cohort

The University of Hong Kong (HKU)

Status: Unknown

Conditions: Alzheimer Dementia; Neurocognitive Disorder; Mild Cognitive Impairment; Vascular Dementia; Age-related Cognitive Decline

Treatments: Biological: Blood tests; Diagnostic Test: MRI; Diagnostic Test: Neurocognitive battery; Diagnostic Test: EEG with event-related potential (ERP); Diagnostic Test: Amyloid PET CT

Study type: Observational

Funder types: Other

Identifiers

NCT03275363

HKUNCDC

Details and patient eligibility

About

The HKU Neurocognitive Disorder (NCD) Cohort is a hospital-based, prospective, observational study of older HK Chinese adults with cognitive impairment, with a special focus on studying patients with subjective cognitive decline and mild cognitive impairment.

Full description

The HKU Neurocognitive Disorder (NCD) Cohort is a hospital-based, prospective, observational study of older HK Chinese adults with cognitive impairment, with a special focus on studying patients with subjective cognitive decline and mild cognitive impairment, and in particular the biomarkers that predict cognitive and functional decline.

Comprehensive profiling of each subject is performed through a multi-domain assessment protocol including detailed demographics, lifestyle factors, neuropsychological battery, mood, MRI, genetics, blood biomarkers, and other patient-centred parameters including level of disability, quality of life and societal engagement. Ongoing annual follow up captures the essential clinical events and changes in neurocognitive function (conversion to MCI or dementia), mood, level of disability and quality of life; as well as repeat blood tests.

The HKU NCD Cohort is the first-ever Asian dementia cohort to be formally included into the Dementia Platforms UK, achieving an international collaborative status with other UK-based cohorts. The study neuropsychological battery is aligned with the NACC UDS3 battery.

Enrollment: 500 estimated patients

Sex: All

Ages: 65+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Older adults with or without neurocognitive disoder. HKU NCD Cohort focuses primarily on people with Subjective Cognitive Decline (SCD) and Mild Cognitive Impairment (MCI).

Exclusion criteria

• Severe Parkinson's disease, major depressive disorder or severe psychiatric conditions, significant communication difficulties (e.g. aphasia, deafness), terminal cancer or likely end-of-life in the next 12 months.

Trial design

500 participants in 5 patient groups

Cognitively normal controls (CNC)

Description:

No subjective memory complaints Normal HK-MoCA Normal instrumental ADL All interventions as described

Treatment:

Diagnostic Test: Neurocognitive battery

Biological: Blood tests

Diagnostic Test: MRI

Diagnostic Test: EEG with event-related potential (ERP)

Subjective cognitive decline (SCD)

Description:

Subjective memory complaints Normal HK-MoCA Normal instrumental ADL All interventions as described

Treatment:

Diagnostic Test: Amyloid PET CT

Diagnostic Test: Neurocognitive battery

Biological: Blood tests

Diagnostic Test: MRI

Diagnostic Test: EEG with event-related potential (ERP)

Mild cognitive impairment (MCI)

Description:

Subjective memory complaints Low HK-MoCA Normal instrumental ADL All interventions as described

Treatment:

Diagnostic Test: Amyloid PET CT

Diagnostic Test: Neurocognitive battery

Biological: Blood tests

Diagnostic Test: MRI

Diagnostic Test: EEG with event-related potential (ERP)

Alzheimer's dementia

Description:

Subjective memory complaints Low HK-MoCA Poor instrumental ADL Probable Alzheimer's disease All interventions as described except EEG with ERP

Treatment:

Diagnostic Test: Amyloid PET CT

Diagnostic Test: Neurocognitive battery

Biological: Blood tests

Diagnostic Test: MRI

Vascular dementia

Description:

Subjective memory complaints Low HK-MoCA Poor instrumental ADL Related to stroke / cerebrovascular disease All interventions as described except EEG with ERP

Treatment:

Diagnostic Test: Amyloid PET CT

Diagnostic Test: Neurocognitive battery

Biological: Blood tests

Diagnostic Test: MRI