The Use of a Forecasting System for Predicting Exacerbations of COPD

AstraZeneca

Status and phase: Completed; Early Phase 1

Conditions: Chronic Obstructive Pulmonary Disease (COPD)

Treatments: Behavioral: COPD self care advice; Behavioral: Poor weather forecast warning

Study type: Interventional

Funder types: Industry

Identifiers

NCT00788645

D6256M00017

Details and patient eligibility

About

People with Chronic Obstructive Pulmonary Disease (COPD) often have periods during the year when their symptoms become worse. These are often due to an infection and are called "exacerbations" by doctors. Exacerbations are more common in the winter and also seem to be related to particular types of weather. As well as forecasting the weather the UK Met Office has developed a system to try to predict when exacerbations are likely to occur. The main purpose of this research study is to find out whether the Met Office forecasting service can predict when exacerbations are more likely to occur and whether the advice given during the predicted higher risk periods leads to fewer patients having an exacerbation or if it reduces the impact of the exacerbation. The study will also assess if there is a link between viral or bacterial infection and breathing problems that occur during the study period. The study will also collect information about possible causes of the breathing problems and what happens to the person afterwards. The results of this study will help us learn more about breathing problems which may lead to new research studies that would aim to improve the care of people with COPD.

Enrollment: 98 patients

Sex: All

Ages: 40+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Current or former smokers with a diagnosis of COPD
• Having impaired lung function as measured by spirometry

Exclusion criteria

• History of asthma or nasal symptoms caused by hayfever
• No telephone
• Inability to record symptoms in an electronic diary (PDA)

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

98 participants in 3 patient groups

Forecast

Experimental group

Description:

COPD patients receiving advice and poor weather warning

Treatment:

Behavioral: COPD self care advice

Behavioral: Poor weather forecast warning

No Forecast

Experimental group

Description:

COPD patients receiving advice and poor weather warning

Treatment:

Behavioral: COPD self care advice

Control

No Intervention group

Description:

Age matched non - COPD subjects