The Use of Angiotensin Converting Enzyme Inhibitors and Incident Respiratory Infections, Are They Harmful or Protective?

University College London (UCL)

Status: Unknown

Conditions: Covid-19, Coronavirus, Angiotensin Converting Enzyme Inhibitors, Influenza, Electronic Health Records, Epidemiology, Comorbidity, Incidence, United Kingdom

Treatments: Drug: ACE inhibitor

Study type: Observational

Funder types: Other

Identifiers

NCT04322786

ISAC17_205R

Details and patient eligibility

About

The study use UK based linked electronic health records from the Clinical Research Datalink (CALIBER) of 5.6 million individuals to conduct a matched case-control study to investigate the incidence of influenza in individuals prescribed ACEI compared to those not prescribed ACEI.

Enrollment: 1,302,508 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• We identify individuals aged 18 years or older and registered in the current primary care practice for at least one year.

Exclusion criteria

• We exclude individuals with a prior history of influenza and viral pneumonia before study entry.

Trial design

1,302,508 participants in 2 patient groups

ACEI user

Description:

Individuals with an ACEI prescription in the study population.

Treatment:

Drug: ACE inhibitor

Matched controls

Description:

Individuals without an ACEI prescription, and matched to the users by sex and 10-year age categories.