The Use of Antibiotic Sinonasal Rinse After Sinus Surgery

University of Miami

Status and phase: Completed; Phase 4

Conditions: Chronic Rhinosinusitis

Treatments: Drug: Placebo; Drug: Mupirocin

Study type: Interventional

Funder types: Other

Identifiers

NCT02218307

20110846

Details and patient eligibility

About

Double blind placebo controlled trial to evaluate whether the routine use of nasal irrigation with mupirocin is more effective than saline irrigations alone in reducing symptoms of chronic rhinosinusitis in the early postoperative period.

Enrollment: 68 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Chronic Rhinosinusitis
• Undergoing endoscopic sinus surgery

Exclusion criteria

• Age under 18
• Documented adverse reaction to mupirocin

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: Double Blind

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68 participants in 2 patient groups, including a placebo group

Mupirocin

Active Comparator group

Description:

topical antibiotic

Treatment:

Drug: Mupirocin

Placebo

Placebo Comparator group

Description:

Placebo control for mupirocin

Treatment:

Drug: Placebo