The Use of Bupivacaine and Ropivacaine for Sciatic Nerve Block

Northwestern University

Status and phase: Completed; Phase 4

Conditions: The Duration of Motor Block May Vary Between 12-36 Hrs

Treatments: Drug: Ropivacaine; Drug: Bupivacaine

Study type: Interventional

Funder types: Other

Identifiers

NCT01272921

STU00035380

Details and patient eligibility

About

The duration of motor block for infragluteal parabiceps sciatic nerve block following total knee replacement may vary between 12-36 hrs depending on the amount of local anesthetic given.

Enrollment: 142 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult patients (>18 years of age) who are undergoing elective total knee arthroplasty will be included in the study.

Exclusion criteria

• Exclusion criteria for the study are patient refusal to be included in the study, contraindications to regional anesthesia, history of allergy to amide local anesthetics, the presence of a progressive neurological deficit, the presence of coagulopathy or infection, or pregnancy

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

---

142 participants in 2 patient groups

Bupivacaine

Active Comparator group

Description:

Varying does to determine duration of analgesia following a sciatic nerve block

Treatment:

Drug: Bupivacaine

Ropivacaine

Active Comparator group

Description:

Varying does to determine duration of analgesia following a sciatic nerve block

Treatment:

Drug: Ropivacaine