The Use of Capsaicin Challenge for Diagnosis, Monitoring and Follow-up of Chronic Cough.

Tel Aviv Sourasky Medical Center

Status: Unknown

Conditions: Chronic Cough

Treatments: Other: capsaicin challenge

Study type: Interventional

Funder types: Other

Identifiers

NCT01807832

TASMC-13-LF-0695-CTIL

Details and patient eligibility

About

The purpose of this study is to determine whether the capsaicin challenge can improve the diagnosis, treatment, monitoring and follow-up in patients with chronic cough.

Full description

Capsaicin is administrated in incremental concentrations with two inhalations of normal saline solution. Patients are instructed to exhale to functional residual capacity and than to inhale through the mouthpiece for 1 second (single breath inhalation). The number of coughs in the first 10 seconds after each inhalation is counted. C2; the concentration of which the patient responded by 2 coughs, C5;the concentration of which the patient responded by 5 coughs. The challenge ends at C5.

Enrollment: 25 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with persisting cough for more than 3 months, without known respiratory or lung diseases

Exclusion criteria

• Diagnosis of respiratory or lung diseases of any kind

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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25 participants in 1 patient group

chronic cough

Other group

Description:

Capsaicine challenge in chronic cough patients

Treatment:

Other: capsaicin challenge