The Use of Castor Oil as a Labor Initiator in Post-date Pregnancies

Hadassah Medical Center

Status: Completed

Conditions: Prolonged Pregnancy

Treatments: Dietary Supplement: Sunflower oil; Dietary Supplement: Castor oil

Study type: Interventional

Funder types: Other

Identifiers

NCT00244738

CASTOR- HMO-CTIL

Details and patient eligibility

About

The purpose of the study is to determine whether castor oil is effective in inducing labor.

Full description

Castor oil is traditionally given by midwives in order to induce labor. Its efficacy as an initiator of labor was previously tested only in one clinical trial. Unfortunately this study (by Garry et al.) was not sufficiently controlled.

We intent to recruit 84 healthy pregnant women with no contraindication to vaginal delivery that had past their due date. Women will be randomly and blindly divided into equal sized intervention group and control group. Intervention group will be given 60 mL of castor oil in 140 mL of orange juice, while control group will be given a placebo with similar texture. Primary outcome to be tested is the percentage of women entering active labor within 24 hours of administration.

Enrollment: 82 patients

Sex: Female

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Pregnant women at 40-42 weeks gestation
• Good obstetrical dating
• Singleton
• Intact membranes
• Preinterventional Bishop score less than or equals 4
• No evidence of effective uterine contractions by external tocography
• Living close to hospital

Exclusion criteria

• Multiple gestation
• Oligohydramnios or Polyhydramnios
• Abnormal FHR tracing
• Obstetric complication (hypertension, bleeding)
• Ruptured membranes
• Suspected intrauterine growth restriction
• Biophysical score < 8
• Previous cesarean section / myomectomy / Other uterine operation
• Fever, malaise at recruitment
• Chronic illness (renal, hepatic, endocrine)

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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82 participants in 2 patient groups, including a placebo group

Intervention

Active Comparator group

Description:

Patients who received castor oil for labor induction

Treatment:

Dietary Supplement: Castor oil

Control

Placebo Comparator group

Description:

Patients who received sunflower oil as a placebo

Treatment:

Dietary Supplement: Sunflower oil