The Use of Isatidis Root and Forsythia Oral Liquid for the Treatment of Mild Cases of COVID-19: A Trial Clinical Study

Central South University

Status and phase: Completed; Phase 1

Conditions: Treatment of Mild Cases of COVID-19

Treatments: Drug: Langenlianqiao; Drug: LianhuaQingWen; Other: placebo control group

Study type: Interventional

Funder types: Other

Identifiers

NCT06355193

MZhou

Details and patient eligibility

About

This study has significant implications for research, as it provides a basis for further studies on the antiviral effects of LGLQ Oral Liquid, encouraging more extensive clinical studies in larger populations and diverse age groups to validate these findings. For medical practice, the findings suggest that LGLQ can be considered an alternative treatment option for mild cases of COVID-19, especially in managing symptoms like fatigue, potentially broadening the range of effective treatments available to healthcare practitioners. In terms of policy, the demonstrated efficacy of LGLQ could lead to its inclusion in treatment guidelines for COVID-19 and other viral infections, fostering a more integrated approach combining Western medicine and Traditional Chinese Medicine in the global fight against pandemics. The insights from this study might prompt health policymakers to reassess the potential of herbal formulations in managing and treating infectious diseases and consider them in the development of future healthcare strategies and policies.

Enrollment: 253 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• the diagnosis of SARS-Cov-2 infection confirmed by quantitative polymerase chain reaction (qPCR) test
• aged 18 years or older
• patients received more than 2 doses of SARS-Cov-2 vaccine
• asymptomatic or mild at the time of hospitalization

Exclusion criteria

• patients with malignant diseases, autoimmune diseases, liver and kidney diseases, blood diseases, neurological diseases, endocrine diseases and other serious diseases may affect the patient's participation in the trial or affect the results of the study
• pregnant women, lactating mothers; allergic conditions
• allergic to the known components of the drug
• patients vaccinated with vaccines less than 1 shot
• Patient does not agree to participate in this study

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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253 participants in 3 patient groups, including a placebo group

LGLQ group

Experimental group

Treatment:

Drug: Langenlianqiao

LHQW group

Experimental group

Treatment:

Drug: LianhuaQingWen

placebo control group

Placebo Comparator group

Treatment:

Other: placebo control group