The Use of Low Molecular Weight Heparin in Hemodiafiltration

Ghent University Hospital (UZ)

Status and phase: Completed; Phase 4

Conditions: Chronic Kidney Disease

Treatments: Procedure: 5 minutes after the start of the session, at the inlet line; Procedure: At start of the session, at the inlet line; Procedure: At the start of the session, at the outlet line

Study type: Interventional

Funder types: Other

Identifiers

NCT00756145

2008/421

Details and patient eligibility

About

Low molecular weight heparin (LMWH) is injected in the dialysis circuit at the start of the session. In the present study we compare 3 different methods of injection of LMWH: parameters of dialysis efficiency and clotting are measured. The study lasts 3 sessions for each patient.

Enrollment: 15 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• chronic kidney disease stade V treated with hemodiafiltration
• age >18 year
• Hematocrit > 30%

Exclusion criteria

• treatment with vitamin K antagonists
• treatment with other anti-coagulants or heparin besides the heparin used during dialysis
• active bleeding, infection or malignancy
• heparin associated allergy
• hepatic failure
• trombocytopenia < 120.000/µl

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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15 participants in 3 patient groups

1

Experimental group

Description:

Injection of LMWH at the start of the hemodiafiltration session, at the inlet bloodline

Treatment:

Procedure: At start of the session, at the inlet line

2

Experimental group

Description:

Injection of LMWH 5 minutes after the start of the hemodiafiltration session, at the inlet bloodline

Treatment:

Procedure: 5 minutes after the start of the session, at the inlet line

3

Experimental group

Description:

Injection of LMWH at the start of the hemodiafiltration session, at the outline bloodline

Treatment:

Procedure: At the start of the session, at the outlet line