The Use of Nomegestrol Acetate/Estradiol in Random Start Rapid Endometrial Preparation

University of Palermo

Status and phase: Completed; Phase 4

Conditions: Endometrial Diseases; Endometrial Polyp

Treatments: Drug: Nomegestrol Acetate/Estradiol 2.5mg/1.5mg

Study type: Interventional

Funder types: Other

Identifiers

NCT06316219

ZOEPREP

Details and patient eligibility

About

The presence of a thin endometrium plays an important role in enabling the best conditions for hysteroscopic surgery. Recently, for this purpose, many studies have evaluated the effect of preoperative administration of a variety of drugs. We explored the efficacy of random started 14-day administration of Nomegestrol Acetate/Estradiol, in rapid preparation of endometrium for hysteroscopic polypectomy.

Enrollment: 80 patients

Sex: Female

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients with endometrial polyps.

Exclusion criteria

• Patients with other endometrial pathologies.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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80 participants in 2 patient groups

Control

No Intervention group

Description:

Patients with endometrial polyps undergone hysteroscopic polipectomy without endometrial preparation.

Intervention

Experimental group

Description:

Patients with endometrial polyps underwent hysteroscopic polipectomy after starting 14-day treatment with oral Nomegestrol Acetate/Estradiol 2.5mg/1.5mg at any time of the menstrual cycle

Treatment:

Drug: Nomegestrol Acetate/Estradiol 2.5mg/1.5mg