The Use of Platelet-rich-fibrin in Lower Third Molar Surgery.

Amerigo Giudice

Status: Completed

Conditions: Tooth, Impacted; Tooth Position Anomalies; Tooth Avulsion; Facial Swelling; Tooth Extraction Status Nos

Treatments: Biological: PRF

Study type: Interventional

Funder types: Other

Identifiers

NCT06165692

2/2023

Details and patient eligibility

About

The present study aims to analyze the effect of PRF (Platelet-rich-fibrin) in terms of facial swelling, trismus and pain after surgical removal of mandibular third molar (M3M) in a split-mouth randomized controlled clinical trial.

Full description

The present study aims to analyze the effect of PRF (Platelet-rich-fibrin) in terms of facial swelling, trismus and pain after surgical removal of mandibular third molar (M3M) in a split-mouth randomized controlled clinical trial. Facial swelling will be assessed using an innovative three-dimensional digital technique.

Enrollment: 31 patients

Sex: All

Ages: 18 to 32 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients aged 18 to 32 years who required both M3M extractions were recruited
• Good health status
• Indication to surgical extraction of both M3M
• Complete root formation
• Surgical risk level classified as "Conventional" or "Moderate" according to Daugela et al. classification

Exclusion criteria

• Person under the age of 18 or over 32
• Allergy or contraindications to administration of corticosteroids
• Acute infection in any of the teeth to be extracted
• Patients with chronic liver disease, diabetes, immune system dysfunction, or haematological disease
• Pregnancy or breastfeeding
• History of treatment with antiresorptive drugs
• Chronic kidney disease

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Triple Blind

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31 participants in 2 patient groups

Test Group

Experimental group

Description:

Placement of PRF in the post-extraction socket after third molar surgery

Treatment:

Biological: PRF

Control Group

No Intervention group

Description:

No positioning PRF in the post-extraction socket after third molar surgery