The Use of Point-of-Care Ultrasound in the Diagnosis of Acute Infectious Mononucleosis in the Emergency Department

Jewish General Hospital

Status: Terminated

Conditions: Splenomegaly; Infectious Mononucleosis

Treatments: Device: Point-of-care ultrasound

Study type: Observational

Funder types: Other

Identifiers

NCT02463669

POCUSIM01

Details and patient eligibility

About

The purpose of this study is to determine if splenomegaly on point-of-care ultrasound (POCUS) is an accurate and user-friendly surrogate to the heterophile antibody test and Epstein-Barr Virus (EBV) serologies to diagnose acute mononucleosis infection in patients presenting with sore throat to the Emergency Department (ED).

Full description

The investigators seek to determine whether the presence of splenomegaly on POCUS can accurately diagnose acute infectious mononucleosis in symptomatic ED patients, and determine the feasibility of performing point-of-care ultrasound for splenomegaly by emergency physicians in the emergency department setting.

Enrollment: 200 patients

Sex: All

Ages: 10 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients aged between 10 and 35 year-old presenting to the ED with suspected acute infectious mononucleosis

Exclusion criteria

• Chronic infectious disorders (eg. tuberculosis, malaria, HIV, syphilis)
• Inflammatory disorders (eg. sarcoidosis, amyloidosis, systemic lupus erythematosus, Felty syndrome)
• Proliferative disorders (eg. lymphoma, leukemia, essential thrombocytopenia, polycythemia vera)
• Congestive disorders (eg: cirrhosis, portal hypertension, right heart failure, congenital heart disease)
• Chronic haemolytic anemia (eg. sickle cell, thalassemia, hereditary spherocytosis)
• Storage diseases (eg. Gaucher, Niemann-Pick)
• Splenectomy
• Inability to give informed consent