The Use of Propranolol for the Prevention of Worsening of Esophageal Varices in Patients With Isolated Gastric Varices

Sichuan University

Status: Unknown

Conditions: Liver Cirrhoses; Portal Hypertension; Gastric Varix

Treatments: Drug: Propranolol

Study type: Interventional

Funder types: Other

Identifiers

NCT03171805

Propranolol in GV

Details and patient eligibility

About

Balloon-occluded retrograde transvenous obliteration (BRTO) has been effective method to manage gastric varices. However, more than one third of patients after BRTO treatment experienced worsening of esophageal varices. The present study was designed to evaluate the effect of post-BRTO propranolol adminstration on the change of esophageal varices.

Enrollment: 74 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Clinical diagnosis of liver cirrhosis
2. Clinical diagnosis of isolated gastric varices
3. The presenec of spontaneous portosystemic shunt

Exclusion criteria

1. Contradictions to Propranolol
2. Balloon occluded retrograde transvenous obliteration was failed

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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74 participants in 2 patient groups

Propranolol group

Experimental group

Description:

Propranolol was given after patients with cirrhosis and isolated gastric varices underwent balloon occluded retrograde transvenous obliteration successfully.

Treatment:

Drug: Propranolol

control group

No Intervention group

Description:

Propranolol was not given after patients with cirrhosis and isolated gastric varices underwent balloon occluded retrograde transvenous obliteration successfully.