The Use of Resting State, fMRI and DTI in the Identification of Chronic Pain Conditions

Brain Scan Inc.

Status: Unknown

Conditions: Chronic Pain

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT02987933

BSI001

Details and patient eligibility

About

Resting state fMRI scans of chronic pain sufferers will be compared to those of healthy normals and may be sufficiently different to allow a high level of classification accuracy of whether subjects have chronic pain. In addition, investigators will utilize DTI and a brief activation state using pain rumination to assess whether investigators can reliably find differences between chronic pain sufferers and healthy normals.

Full description

Resting state fMRI scans of chronic pain sufferers may be sufficiently different from scans of normal subjects to allow a high level of classification accuracy of whether subjects have chronic pain. In addition, investigators will utilize DTI and a brief activation state using pain rumination to assess whether investigators can reliably find differences between chronic pain sufferers and healthy normals. The analysis will use pattern recognition methods in a leave N out cross validation design. The success of the classifications will be the mean of all the validation runs.

Enrollment: 40 estimated patients

Sex: All

Ages: 20 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Daily Pain lasting for more than 6 months. Ages eligible for study are between 20 and 70 years.

Exclusion criteria

Adults unable to consent Children, teenagers Pregnant women Prisoners Subjects who do not know English MRI exclusion criteria

Trial design

40 participants in 2 patient groups

Chronic Pain

Description:

Adults, \> 6 months duration, daily pain

Healthy Normals

Description:

Age and gender matched controls