The Use of Rhythmic Light Therapy in Mild Cognitive Impairment

Mount Sinai Health System

Status: Enrolling

Conditions: Mild Cognitive Impairment

Treatments: Device: Flickering Light

Study type: Interventional

Funder types: Other

Identifiers

NCT07318038

STUDY-25-01233

Details and patient eligibility

About

In this within-subjects, crossover study, participants will undergo Electroencephalogram (EEG) recordings before, during, and after each of three 1-hour sessions. All participants will experience all three conditions: (1) dual-frequency visual (10 and 40 Hz), (2) single-frequency visual (40 Hz), and (3) non-rhythmic stimulation. EEG spectral power and amplitude coupling will be analyzed to determine whether stimulation-induced increases in alpha-gamma neural synchrony translate to improvements in cognitive performance.

Enrollment: 20 estimated patients

Sex: All

Ages: 55 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• History of Mild Cognitive Impairment with a Montreal Cognitive Assessment score between 18 and 25

Exclusion criteria

• History of epilepsy or photosensitivity
• Blindness or other obstructive vision conditions
• retinal diseases
• presence of another brain disease accounting for their cognitive status

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

---

20 participants in 3 patient groups, including a placebo group

Dual frequency flickering light

Experimental group

Description:

Light flickering with 10 Hz + 40 Hz visual stimulation

Treatment:

Device: Flickering Light

Single frequency flickering light

Experimental group

Description:

Light flickering with 10 Hz visual stimulation

Treatment:

Device: Flickering Light

non-rhythmic flickering light

Placebo Comparator group

Description:

Light flickering with random visual stimulation

Treatment:

Device: Flickering Light