The Use of Self-reported Symptoms as a Proxy for Acute Organophosphate Poisoning Among Nepali Farmers

Bispebjerg Hospital

Status: Completed

Conditions: Organophosphate Poisoning

Treatments: Other: Placebo; Other: Organophosphate

Study type: Interventional

Funder types: Other

Identifiers

NCT02838303

12205-01-57-02

Details and patient eligibility

About

The purpose of this study is to evaluate self-reported symptoms as a proxy for acute organophosphate poisoning by examining self-reported acute organophosphate poisoning symptoms and PchE activity in response to occupational acute organophosphate exposure among farmers in Nepal.

Enrollment: 42 patients

Sex: Male

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• male
• minimum age 18 years
• hand pressured backpack sprayer usage
• used to spray with moderately to extremely hazardous pesticides according to the World Health Organization's (WHO) Pesticide Hazard Classification

Exclusion criteria

• usual personal protective equipment use (respirator/mask with particulate filter, face shield, googles, gloves, boots, plastic poncho)
• unwilling to stay pesticide-free seven days prior to each of the two spray sessions
• medical conditions interfering with PchE activity (liver disease, acute infection, chronic malnutrition, heart attack, cancer, obstructive jaundice, inflammation caused by various diseases, or use of pyridostigmine drugs)

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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42 participants in 2 patient groups

Group A

Other group

Description:

Initial spray session: organophosphate. Crossover spray session: placebo

Treatment:

Other: Placebo

Other: Organophosphate

Group B

Other group

Description:

Initial spray session: placebo. Crossover spray session: organophosphate

Treatment:

Other: Placebo

Other: Organophosphate