The Use of Thrombin Generation Assay in Detection of Central Line Related Thrombosis (CRT) in Critically Ill Patients (THROM-CRIT)

Queen Mary Hospital

Status: Enrolling

Conditions: Thrombosis, Venous; Central Line Complication

Treatments: Diagnostic Test: Thrombin generation assay

Study type: Observational

Funder types: Other

Identifiers

NCT06094387

20230905-017-000

Details and patient eligibility

About

To study thrombin generation parameters in critically ill patients with and without central line related thrombosis (CRT).

Enrollment: 30 estimated patients

Sex: All

Ages: 18 to 100 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age ≧ 18; AND
• Admitted to the mixed medical-surgical intensive care units of Queen Mary Hospital in Hong Kong; AND
• Clinically indicated for central catheter insertion, which includes central venous catheters and dialysis catheters; AND
• Expected to have the central catheter in place for at least 5 days in their ICU stay.

Exclusion criteria

• Patients known to have active venous thromboembolism including deep venous thrombosis or pulmonary embolism;
• Patients known to have hypercoagulable states, e.g., hereditary thrombophilia, antiphospholipid syndrome; OR
• Patients with active solid organ or hematological malignancies; OR
• Patients already receiving therapeutic anticoagulation prior to study recruitment; OR
• Patients with thrombosis detected in the insertion site before central catheter insertion; OR
• Patients with a central venous catheter already in place prior to ICU admission; OR
• Patients admitted to the ICU for post-operative care; OR
• Patients admitted to the ICU for trauma care; OR
• Patients requiring extra-corporeal life support (ECLS); OR
• Patients with poor window or inaccessible for ultrasonographic examination; OR
• Pregnancy/post-partum within 6 weeks