The Usefulness of Myocardial Work IndeX in ExtraCorporeal Membrane Oxygenation Patients (MIX-ECMO)

Semmelweis University

Status: Not yet enrolling

Conditions: Extracorporeal Membrane Oxygenation Complication; Myocardial Failure; Echocardiography; Cardiogenic Shock; Mechanical Circulatory Support

Study type: Observational

Funder types: Other

Identifiers

NCT05838937

BMEÜ/4229- 1 /2022/EKU

Details and patient eligibility

About

Investigation of the potential prognostic role of non-invasive myocardial work in patients receiving veno-arterial extracorporeal membrane oxygenation therapy.

Full description

The study aims to examine the prognostic role of non-invasive myocardial work in veno-arterial extracorporeal membrane oxygenation therapy patients. Subjects with cardiogenic shock regardless of etiology will be enrolled 48-72 hours after the initiation of mechanical circulatory support. It is hypothesized that non-invasive myocardial work may be an independent prognosticator of the outcome.

Enrollment: 100 estimated patients

Sex: All

Ages: 18 to 99 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 18 years or older age
• Severe cardiogenic shock requiring the initiation of VA-ECMO therapy
• Stabile hemodynamic state and oxigenation with VA-ECMO and vasoactive support
• Informed written consent (due to the nature of the study, from a legally eligible relative of the patient)

Exclusion criteria

• Younger than 18 years of age
• Unstable hemodynamic state or suboptimal oxigenation despite established VA-ECMO and vasoactive support
• Severe neurological damage or confirmed brain death at the time of enrollment which squarely indicates therapy limitation and poor short-term outcome
• Transesophageal echocardiography is contraindicated
• Suboptimal echocardiographic window

Trial design

100 participants in 1 patient group

Investigation cohort

Description:

Cardiogenic shock patients from any cause receiving veno-arterial extracorporeal membrane oxygenation