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The Utility of Thromboelastography in Cirrhotic Patients Undergoing Endoscopic Procedures

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Johns Hopkins University

Status

Terminated

Conditions

Cirrhosis, Coagulopathy

Treatments

Biological: Blood transfusion

Study type

Interventional

Funder types

Other

Identifiers

NCT02990273
IRB00113092

Details and patient eligibility

About

Cirrhosis results in decreased synthesis of both procoagulants and anticoagulants resulting in "rebalanced homeostasis". However, conventional blood tests (platelets/ INR levels) that are performed prior to invasive procedures do not accurately reflect the coagulation changes that occur in cirrhotics, resulting in unnecessary transfusion of blood products. Thromboelastography (TEG) is a global hemostasis assessment tool that is being used in surgery (including liver transplant) to help guide blood product transfusion in the operating room. The investigators would like to compare the use of TEG vs. INR/platelets to help guide blood product transfusion in cirrhotic patients undergoing inpatient endoscopy. The investigators will evaluate to see if there is a decrease in prophylactic blood transfusions prior to endoscopy when using TEG.

Enrollment

1 patient

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • All 18 yo + cirrhotic patients who are being scheduled for inpatient endoscopy

Exclusion criteria

  • Patients on blood thinners (prophylactic anticoagulation is permissible)
  • Hemodynamically unstable patients requiring pressors (ie ICU level patients)
  • Pregnant or lactating individuals
  • Inability to provide consent for any reason

Trial design

Primary purpose

Diagnostic

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

1 participants in 2 patient groups

TEG
Active Comparator group
Description:
Blood transfusion
Treatment:
Biological: Blood transfusion
Prothrombin Time (PT)/International normalized ratio (INR)
Active Comparator group
Description:
Blood transfusion
Treatment:
Biological: Blood transfusion

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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