The Utility of Thromboelastography in Traumatic Brain Injury

Shanghai Jiao Tong University

Status: Enrolling

Conditions: Traumatic Brain Injury; Coagulation Disorder

Study type: Observational

Funder types: Other

Identifiers

NCT04524637

18PJD034

Details and patient eligibility

About

Hemocoagulation disorder is recognized to have crucial effects on hemorrhagic or ischemic diseases. Coagulation-related damages secondary to traumatic brain injury are common and severe secondary insults of head trauma and often leads to a poor prognosis. In this study, we sought to assess if posttraumatic hemocoagulation disorders determined using thromboelastography are associated with coagulation-related damages secondary to traumatic brain injury, and evaluate their influence on outcome among patients with head trauma. Based on above results, prediction models or risk scoring systems will be further developed and validated to predict coagulation-related damages secondary to traumatic brain injury.

Enrollment: 500 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients who are delivered to hospital within 24 hours after head trauma
• Patients whose abbreviated injury score (AIS) for other body regions is 3 or less are considered to be isolated traumatic brain injury

Exclusion criteria

• Patients with existing prior neurological disease
• Patients with known coagulation disorders
• Patients on anticoagulants and medications known to affect coagulation function within 30 days before trauma
• Patients receiving blood components prior to blood draw
• Patients who deteriorate and die before determining whether coagulation- related damage exists

Trial design

500 participants in 1 patient group

Traumatic brain injury

Description:

Patients who are delivered within 24 hours after head trauma and sustain isolated traumatic brain injury are included in this study.