The Value of Diffusion-weighted Imaging in Evaluating the Early Efficacy of Liver Metastasis in Colorectal Cancer

Fudan University

Status: Unknown

Conditions: DWI-MRI

Treatments: Device: Diffusion weighted magnetic resonance imaging

Study type: Interventional

Funder types: Other

Identifiers

NCT03088163

FDZL-MRinCLM

Details and patient eligibility

About

The study is designed to evaluate the value of DWI-MRI (Diffusion weighted magnetic resonance imaging) in predicting the efficacy of liver metastases after chemotherapy in colorectal cancer.

Enrollment: 100 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• aged ≥18 years with histologically or cytologically confirmed advanced colorectal adenocarcinoma
• Eastern Cooperative Oncology Group performance status of 0 to 2
• life expectancy of ≥ 3 months
• at least one measurable liver metastatic lesion in MRI (≥10mm)
• have adequate bone marrow, hepatic, and renal function
• previously received no palliative chemotherapy

Exclusion criteria

• patients with previous chronic inflammatory bowel disease, chronic diarrhea or recurrent bowel obstruction
• patients with symptomatic brain metastases
• active clinical severe infection
• have contraindication of MRI screening

Trial design

Primary purpose: Device Feasibility

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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100 participants in 1 patient group

DWI-MRI

Experimental group

Treatment:

Device: Diffusion weighted magnetic resonance imaging