The Value of Progesterone for the Timing of the Embryo Transfer in IVF/ICSI: a Prospective Randomised Trial

Ghent University Hospital (UZ)

Status: Completed

Conditions: Clinical Pregnancy Rate

Treatments: Procedure: Freeze all

Study type: Interventional

Funder types: Other

Identifiers

NCT03162315

B670201627451

Details and patient eligibility

About

At the start of the controlled ovarian stimulation as a part of the IVF/ICSI treatment patients are informed about this trial. In case they gave informed consent and they have a progesterone level between 1 and 1.5 ng/ml at the day of the hCG injection, they will be randomised. One group of patients will have a fresh embryo transfer, in the second group all embryos will be cryopreserved and transfered in a subsequent (natural or artificial) cycle. The aim of this study is to compare clinical pregnancy rate between the two groups.

Enrollment: 24 patients

Sex: Female

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• IVF/ICSI treatment
• progesterone > 1 ng/ml and ≤ 1.5 ng/ml

Exclusion criteria

• > 40 years
• AMH ≤ 1 ng/ml
• Conditions influencing pregnancy rate (e.g. hydrosalphinx, uterus malformation, hyperprolactinemia and other endocrine conditions; with the exception of controlled thyroid function disease)
• no available progesterone value on the day of hCG-injection

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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24 participants in 2 patient groups

Fresh embryo transfer

No Intervention group

Description:

fresh embryo transfer (standard of care)

Freeze all

Experimental group

Description:

Vitrification of all embryos and replacement of a thawed embryo in a subsequent cycle

Treatment:

Procedure: Freeze all