The Value of PSP in Predicting Outcome in ICU Surgical Peritonitis Patients

University of Magdeburg

Status: Completed

Conditions: Multiple Organ Failure; Death; Peritonitis; Sepsis

Treatments: Radiation: Imaging; Procedure: Intubation; Procedure: All abdominal surgical procedures

Study type: Observational

Funder types: Other

Identifiers

NCT01465711

33/01

Details and patient eligibility

About

The purpose of this study is to determine the diagnostic accuracy of Pancreatic Stone Protein (PSP) in predicting patient outcomes with suspected peritonitis in the Intensive Care Unit after abdominal surgery and compare PPS with other blood parameters, including C-Reactive Protein (CRP), White Cell Count (WCC), Interleucin-6 (IL-6) and Procalcitonin (PCT).

Full description

Peritonitis is a severe complication after abdominal surgery. Patients admitted at the Intensive Care Unit (ICU) following surgery bear the risk of localized infection, sepsis or septic shock. Prevention or early detection of such events is important to intervene with an appropriate therapeutic action and avoid risking a potentially life-threatening situation. White blood cell counts (WCC) and C-Reactive Protein (CRP), Interleucin-6 (IL-6) and Procalcitonin (PCT) have all been promising parameters, however, they are useful only in selective cases and have a limited diagnostic accuracy.

Enrollment: 137 patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Abdominal surgery.
• Admission to the Intensive Care Unit (ICU).
• Blood sampling within 3 hours from admission to the ICU
• Patient over 18 years of age

Exclusion criteria

• Patients already treated for peritonitis.
• Patients referred from other hospitals with suspicion of peritonitis
• Patient age less than 18 years of age.

Trial design

137 participants in 2 patient groups

Control

Description:

Admission to the Intensive Care Unit (ICU) after abdominal surgery without suspicion / evidence of peritonitis.

Treatment:

Procedure: All abdominal surgical procedures

Radiation: Imaging

Procedure: Intubation

Peritonitis

Description:

Admission to the Intensive Care Unit (ICU) after abdominal surgery with suspicion / evidence of peritonitis

Treatment:

Procedure: All abdominal surgical procedures

Radiation: Imaging

Procedure: Intubation