The Value of Using Platelet Rich Plasma After Hysteroscopic Lysis of Severe Intrauterine Adhesions

Ain Shams Maternity Hospital

Status: Completed

Conditions: Intrauterine Adhesion

Treatments: Device: Intrauterine Foley's Catheter; Biological: Platelet Rich Plasma

Study type: Interventional

Funder types: Other

Identifiers

NCT03541746

PRP-HLIUA

Details and patient eligibility

About

The aim of present study is to evaluate the effect of the use of platelet rich plasma in decreasing recurrence of intrauterine adhesions after its lysis.

Full description

Research question:

In women undergoing hysteroscopic adhesiolysis, does postoperative use of platelet rich plasma decrease the recurrence of intrauterine adhesions?

Research hypothesis:

In women undergoing hysteroscopic adhesiolysis for Asherman's syndrome, postoperative use of platelet rich plasma may decrease the recurrence of intrauterine adhesions.

Enrollment: 60 patients

Sex: Female

Ages: 18 to 43 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Infertility due to Asherman's syndrome with history of hypomenorrhea or amenorrhea and infertility and evaluated by office hysteroscopy to confirm the presence of sever adhesions according to American fertility society.

Exclusion criteria

• Hb < 11 g/dL, platelets < 150.000/mm3
• Patient taking anticoagulant.
• Patient taking NSAID in the 10 days before procedure.
• Any significant comorbidity or psychiatric disorder that would compromise patient's consent.
• Active cervical or uterine infection.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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60 participants in 2 patient groups

Study Group

Experimental group

Description:

Platelet Rich Plasma

Treatment:

Biological: Platelet Rich Plasma

Control Group

Active Comparator group

Description:

Intrauterine Foley's Catheter

Treatment:

Device: Intrauterine Foley's Catheter